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      CONTENTS

      1  2.1 Introduction

      2  2.2 Drug Interactions Mediated by Enzymes and Transporters at Various Sites

      3  2.3 Factors Affecting DDI

      4  2.4 In Vitro Methods to Evaluate Drug–Drug Interactions 2.4.1 Candidate Drug as a Potential Perpetrator 2.4.2 Candidate Drug as a Potential Victim of Inhibition

      5  2.5 Sources of Uncertainty

      6  2.6 Therapeutic Protein–Drug Interaction Keywords References

Schematic illustration of potential sources of DDI risks for a new molecular entity.
DDI mechanisms Liver Intestine Kidney Blood–brain barrier

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