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Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. • Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry • Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research • Features case studies to illustrate practical challenges and solutions in formulation selection • Covers regulatory filing, drug metabolism and physical and chemical properties, toxicology formulation, biopharmaceutics classification system (BCS), screening approaches, early stage clinical formulation development, and outsourcing

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A Dictionary of Postmodernism presents an authoritative A-Z of the critical terms and central figures related to the origins and evolution of postmodernist theory and culture. Explores the names and ideas that have come to define the postmodern condition – from Baudrillard, Jameson, and Lyotard, to the concepts of deconstruction, meta-narrative, and simulation – alongside less canonical topics such as dialogue and punk Includes essays by the late Niall Lucy, a leading expert in postmodernism studies, and by other noted scholars who came together to complete and expand upon his last work Spans a kaleidoscope of postmodernism perspectives, addressing its lovers and haters; its movers and shakers such as Derrida; its origins in modernism and semiotics, and its outlook for the future Features a series of brief essays rather than fixed definitions of the key ideas and arguments Engaging and thought-provoking, this is at once a scholarly guide and enduring reference for the field

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This is a concise yet comprehensive treatment of the American short story that includes an historical overview of the topic as well as discussion of notable American authors and individual stories, from Benjamin Franklin’s “The Speech of Miss Polly Baker” in 1747 to “The Joy Luck Club”. Includes a selection of writers chosen not only for their contributions of individual stories but for bodies of work that advanced the boundaries of short fiction, including Washington Irving, Sarah Orne Jewett, Stephen Crane, Jamaica Kincaid, and Tim O’Brien Addresses the ways in which American oral storytelling and other narrative traditions were integral to the formation and flourishing of the short story genre Written in accessible and engaging prose for students at all levels by a renowned literary scholar to illuminate an important genre that has received short shrift in scholarly literature of the last century Includes a glossary defining the most common terms used in literary history and in critical discussions of fiction, and a bibliography of works for further study

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Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry. • Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems • Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations • Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach • Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world

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This book covers both the mathematics of inverse problems and optical systems design, and includes a review of the mathematical methods and Fourier optics. The first part of the book deals with the mathematical tools in detail with minimal assumption about prior knowledge on the part of the reader. The second part of the book discusses concepts in optics, particularly propagation of optical waves and coherence properties of optical fields that form the basis of the computational models used for image recovery. The third part provides a discussion of specific imaging systems that illustrate the power of the hybrid computational imaging model in enhancing imaging performance. A number of exercises are provided for readers to develop further understanding of computational imaging. While the focus of the book is largely on optical imaging systems, the key concepts are discussed in a fairly general manner so as to provide useful background for understanding the mechanisms of a diverse range of imaging modalities.

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This book advocates a more thoughtful approach to urban water management. The approach involves reducing water consumption, harvesting rainwater, recycling rainwater and adopting Sustainable Drainage Systems (SuDS) where surface water is not sent straight to drains but is intercepted by features like green roofs, rain gardens, swales and ponds.Cities in particular need to change the existing linear model of water consumption and use to a more circular one in order to survive. The Water Sensitive City brings together the various specialised technical discussions that have been continuing for some time into a volume that is more accessible to designers (engineers and architects), urban planners and managers, and policymakers.

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This accessible, clear and concise textbook strikes a balance between theory and practical applications for an introductory course in soil mechanics for undergraduates in civil engineering, construction, mining and geological engineering. Soil Mechanics Fundamentals lays a solid foundation on key principles of soil mechanics for application in later engineering courses as well as in engineering practice. With this textbook, students will learn how to conduct a site investigation, acquire an understanding of the physical and mechanical properties of soils and methods of determining them, and apply the knowledge gained to analyse and design earthworks, simple foundations, retaining walls and slopes. The author discusses and demonstrates contemporary ideas and methods of interpreting the physical and mechanical properties of soils for both fundamental knowledge and for practical applications. The chapter presentation and content is informed by modern theories of how students learn: Learning objectives inform students what knowledge and skills they are expected to gain from the chapter. Definitions of Key Terms are given which students may not have encountered previously, or may have been understood in a different context. Key Point summaries throughout emphasize the most important points in the material just read. Practical Examples give students an opportunity to see how the prior and current principles are integrated to solve ‘real world’ problems.

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To understand climate change today, we first need to know how Earth’s climate changed over the past 450 million years. Finding answers depends upon contributions from a wide range of sciences, not just the rock record uncovered by geologists. In Earth’s Climate Evolution, Colin Summerhayes analyzes reports and records of past climate change dating back to the late 18th century to uncover key patterns in the climate system. The book will transform debate and set the agenda for the next generation of thought about future climate change. The book takes a unique approach to the subject providing a description of the greenhouse and icehouse worlds of the past 450 million years since land plants emerged, ignoring major earlier glaciations like that of Snowball Earth, which occurred around 600 million years ago in a world free of land plants. It describes the evolution of thinking in palaeoclimatology and introduces the main players in the field and how their ideas were received and, in many cases, subsequently modified. It records the arguments and discussions about the merits of different ideas along the way. It also includes several notes made from the author’s own personal involvement in palaeoclimatological and palaeoceanographic studies, and from his experience of working alongside several of the major players in these fields in recent years. This book will be an invaluable reference for both undergraduate and postgraduate students taking courses in related fields and will also be of interest to historians of science and/or geology, climatology and oceanography. It should also be of interest to the wider scientific and engineering community, high school science students, policy makers, and environmental NGOs. Reviews: «Outstanding in its presentation of the facts and a good read in the way that it intersperses the climate story with the author's own experiences. [This book] puts the climate story into a compelling geological history.» -Dr. James Baker «The book is written in very clear and concise prose, [and takes] original, enlightening, and engaging approach to talking about 'ideas' from the perspective of the scientists who promoted them.» -Professor Christopher R. Scotese «A thrilling ride through continental drift and its consequences.» – Professor Gerald R. North «Written in a style and language which can be easily understood by laymen as well as scientists.» – Professor Dr Jörn Thiede «What makes this book particularly distinctive is how well it builds in the narrative of change in ideas over time.» – Holocene book reviews, May 2016 «This is a fascinating book and the author’s biographical approach gives it great human appeal.» – E Adlard

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This book begins with the premise that energy demands are directing scientists towards ever-greener methods of power management, so highly integrated power control ICs (integrated chip/circuit) are increasingly in demand for further reducing power consumption. A timely and comprehensive reference guide for IC designers dealing with the increasingly widespread demand for integrated low power management Includes new topics such as LED lighting, fast transient response, DVS-tracking and design with advanced technology nodes Leading author (Chen) is an active and renowned contributor to the power management IC design field, and has extensive industry experience Accompanying website includes presentation files with book illustrations, lecture notes, simulation circuits, solution manuals, instructors’ manuals, and program downloads

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Ethnopharmacology is one of the world’s fastest-growing scientific disciplines encompassing a diverse range of subjects. It links natural sciences research on medicinal, aromatic and toxic plants with socio-cultural studies and has often been associated with the development of new drugs. The Editors of Ethnopharmacology have assembled an international team of renowned contributors to provide a critical synthesis of the substantial body of new knowledge and evidence on the subject that has emerged over the past decade. Divided into three parts, the book begins with an overview of the subject including a brief history, ethnopharmacological methods, the role of intellectual property protection, key analytical approaches, the role of ethnopharmacology in primary/secondary education and links to biodiversity and ecological research. Part two looks at ethnopharmacological contributions to modern therapeutics across a range of conditions including CNS disorders, cancer, bone and joint health and parasitic diseases. The final part is devoted to regional perspectives covering all continents, providing a state-of-the –art assessment of the status of ethnopharmacological research globally. A comprehensive, critical synthesis of the latest developments in ethnopharmacology. Includes a section devoted to ethnopharmacological contributions to modern therapeutics across a range of conditions. Contributions are from leading international experts in the field. This timely book will prove invaluable for researchers and students across a range of subjects including ethnopharmacology, ethnobotany, medicinal plant research and natural products research. Ethnopharmacology- A Reader is part of the ULLA Series in Pharmaceutical Sciences www.ullapharmsci.org

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