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Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.

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Designed to provide students with a foundation in understanding and interpreting histologic and cytologic preparations, Color Atlas of Veterinary Histology is a practical benchside reference focusing on the normal histology of eight common domestic species. This Third Edition has been revised with new images, information, and updated terminology throughout. Introductory chapters have also been expanded to offer more complete coverage of the basic types of tissues, providing an even more thorough grounding in the principles of histology. For the first time, the more than 900 photomicrographs are available digitally in an interactive atlas on CD, offering images available for download with zoom capability. The new edition of this veterinary-specific histology atlas provides veterinary and veterinary technician students with an essential pictorial resource for interpreting histologic preparations.

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Oral Microbiology At A Glance is a title in the highly popular at a Glance series. It provides a concise and accessible introduction and revision aid. Following the familiar, easy-to-use at a Glance format, each topic is presented as a double-page spread with key facts accompanied by clear diagrams encapsulating essential information. Systematically organized and succinctly delivered, Oral Microbiology At A Glance covers: Oral microbial origins of health or disease Various infections ranging from dental caries, periodontal and endodontic infections to oral mucosal, bone, and systemic infections Local and systemic extensions of oral infections Sterilization, disinfection, infection control methods, and bioterrorism Oral Microbiology At A Glance is the ideal companion for students of microbiology, all students of dentistry, and early career clinicians. In addition the text will provide valuable insight for general dental practitioners wanting to update their knowledge of oral microbiology and immunology, as well as dental hygienists, therapists and technicians.

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An understanding of current trauma imaging concepts is essential for all medical personnel involved in the care of trauma patients where the outcome may depend on a rapid assessment of the nature and severity of injuries, allowing appropriate medical management and surgical or non-surgical intervention. Containing more than 300 state of the art full colour images, the ABC of Imaging in Trauma addresses this increasingly important area and provides a concise and practical guide to the role, performance and interpretation of emergency imaging procedures in disaster victims and major trauma patients, and focuses on the use of CT, ultrasound, and MRI scanning to diagnose such patients. It is ideal for the non specialist and emergency physicians, Foundation doctors, trainee radiologists, and specialist trauma nurses. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.

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This text provides students a foundation in public health practice and management, focusing on developing the knowledge and skills required by the real world of public health. The authors of Transforming Public Health Practice explain the drivers of change in public health practice, key success factors for public health programs, dealing with the chronic disease burden, the impact of national health policy on public health practice, and tools for understanding and managing population health. Transforming Public Health Practice covers core leadership and management skills, covering areas such as politics, workforce, partnership and collaboration, change management, outcomes orientation, opportunities for improvement, health equity, and future challenges. Case studies highlight innovations in health education, working with people with disabilities, partnerships in response to disease outbreaks, and health programs. Learning objectives, chapter summaries, key terms, and discussion questions enhance each chapter. A downloadable instructors' supplement is available on the companion Web site for the book.

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Medical Genetics at a Glance covers the core scientific principles necessary for an understanding of medical genetics and its clinical applications, while also considering the social implications of genetic disorders. This third edition has been fully updated to include the latest developments in the field, covering the most common genetic anomalies, their diagnosis and management, in clear, concise and revision-friendly sections to complement any health science course. Medical Genetics at a Glance now has a completely revised structure, to make its content even more accessible. Other features include: • Three new chapters on Gene Identification, The Biology of Cancer, and Genomic Approaches to Cancer • A much extended treatment of Biochemical Genetics • A completely revised chapter on The Cell Cycle, explaining principles of biochemistry and genetics which are fundamental to understanding cancer causation • Two new chapters on Cardiac Developmental Pathology • An extended Case Studies section Providing a broad understanding of one of the most rapidly progressing topics in medicine, Medical Genetics at a Glance is perfect for students of medicine, molecular biology, genetics and genetic counselling, and is a previous winner of a BMA Award.

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Taking the problem-based approach, this text helps clinicians improve their diagnostic and therapeutic skills in a focused and practical manner. The cases included demonstrate the diversity of clinical practice in the specialty worldwide, and are divided into five major sections: Upper GI, Pancreato-Biliary, Liver, Small and Large Bowel, and Miscellaneous.

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В книге приведены современные представления о медицинской реабилитации. В первой части проанализирована информация общего характера о теории и методологии реабилитологии. Во второй части изложены факты по частной реабилитологии и даны практические рекомендации по ведению пациентов на реабилитационном этапе: рассмотрены оптимальные комплексы реабилитационных мероприятий при наиболее распространенной патологии – сердечно-сосудистые заболевания, инсульт, патология суставов различного генеза, травматология, онкология. Книга предназначена для врачей-реабилитологов, терапевтов, кардиологов, неврологов, врачей общей практики, травматологов-ортопедов, онкологов, физиотерапевтов и представителей смежных специальностей.

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Книга представляет собой готовое к внедрению руководство по качеству в клинической трансфузиологии. Данное руководство состоит из отдельных блоков – стандартных операционных процедур, в каждом из которых подробно описывается один из этапов работы врача в области трансфузиологии и эфферентной терапии.

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Целью книги является углубленное ознакомление врачей с методикой продленной вено-венозной гемофильтрации – выставление показаний и противопоказаний на основании современных рекомендаций лечения в интенсивной терапии.

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