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Thermodynamics and Kinetics of Drug Binding. Hugo Kubinyi
Медицина.Информация о книге
Название Thermodynamics and Kinetics of Drug Binding
Год выпуска 0
isbn 9783527673049
Автор произведения Hugo Kubinyi
Жанр Медицина
Издательство John Wiley & Sons Limited
Аннотация
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.